VNS Therapy is proven safe and effective for treating uncontrolled seizures in children and adults

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*VIEW IMPORTANT SAFETY INFORMATION

VNS Therapy is the #1 prescribed device to treat epilepsy

>100,000 patients treated

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VNS Therapy is the only device for drug-resistant epilepsy that is FDA-approved for 1.5T and 3T MRI

MRI Guidelines >

Introducing SenTiva and the Next-Generation Programming System

This changes everything.

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Smart Technology. Customizable Therapy. Based on Proven Results.

VNS Therapy controls seizures in 3 ways¹

Prevent

Normal Mode

Prevent seizures with long-term effectiveness²

Therapy delivered at regular intervals all day, everyday¹

Respond

AutoStim Mode

Automatically attempts to stop or shorten a seizure, improve recovery³

Automatic delivery of therapy activated by a proven seizure biomarker⁴

On-Demand

Magnet Mode

Attempts to stop or shorten a seizure, improve recovery³

Manually activated delivery of acute therapy¹

How VNS Therapy with responsive stimulation works

Detection and responsive stimulation during a seizure^*5,6

*Single patient example from clinical trial. Individual results may vary.

Clinical Benefits

What do patients say are the benefits of VNS Therapy?

The benefits of VNS Therapy are seen early—often within 3 months⁷—and continue to improve out to 10 years⁸

SUDEP^*

Lower Risk of SUDEP for Patients with VNS Therapy over Time^9,10

Multiple long-term studies support:

SUDEP risk significantly decreases during long-term follow-up of patients receiving VNS Therapy^9,10

*Sudden Unexplained Death in Epilepsy

SEIZURE COUNT

Fewer Seizures

Sustained Control

Improves over Time^2,8

Multiple long-term studies support:

≥ 90% seizure reduction achieved in 1 out of 4 patients^11,12

≥ 50% seizure reduction achieved in half to two-thirds of patients^11-15

SEIZURE IMPACT

Shorter Seizures

Reduced Severity

Improved Recovery²

Multiple long-term studies support:

Significant reduction in seizure duration, severity, and improved post-ictal recovery in children and adults^7,16

QUALITY OF LIFE

Improved Mood, Memory, and Alertness²

3 out of 4 patients report a net improvement in QoL¹⁷

Multiple long term studies support:

Significant reduction in status epilepticus¹⁸, ER visits, and hospitalizations by up to 50%^18,19

Proven safe and effective

No drug interactions or drug-related toxic central nervous system side effects²

Most common adverse events with VNS Therapy diminish over time^20,21

Publications

SUDEP

Long-Term Surveillance of SUDEP in Drug-Resistant Epilepsy Patients Treated with VNS Therapy

Ryvlin P, et al. Epilepsia. 2018; 59:562–572.

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AutoStim

A prospective, multicenter study of cardiac-based seizure detection to activate vagus nerve stimulation

Boon P, et al. Seizure. 2015; 32: 52-61.

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AutoStim

Automatic Vagus Nerve Stimulation Triggered by Ictal Tachycardia: Clinical Outcomes and Device Performance—The U.S. E‐37 Trial

Fisher RS, et al. Neuromodulation. 2016; 19: 188-195.

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Quality of Life

Quality-of-life metrics with vagus nerve stimulation for epilepsy from provider survey data

Englot DJ, et al. Epilepsy & Behavior. 2017; 66:4–9.

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Patient Stories

After VNS Therapy... I stepped out of the darkness and into the light.

- Starr, on VNS Therapy since 2003

Before VNS therapy, I was having multiple seizures a day. After VNS therapy, the last seizure I’ve had was a few months ago.

- Aaron, on VNS Therapy since 2008

Her quality of life has—it’s just changed. It’s just miraculous. It’s been a lifesaver.

- Nicole, Vivien's Mother
Vivien, on VNS Therapy since 2015

Find out more here

Browse Resources Contact Us

1. VNS Therapy Physician’s Manual, LivaNova, Inc. Houston, TX. 2. Epilepsy Patient's Manual for Vagus Nerve Stimulation, LivaNova, Inc., Houston, TX. 3. Fisher RS, et al. Neuromodulation. 2016; 19: 188‐195. 4. Eggleston KS, et al. Seizure 2014;23(7):501. 5. Data on File, LivaNova, Inc., Houston, TX. 6. Adapted from Boon P, et al. Seizure. 2015; 32: 52‐61. 7. Boon P, et al. Seizure. 2015; 32: 52‐61. 8. Elliott RE, et al. Epilepsy Behav 2011;20(3):478‐483. 9. Ryvlin P, et al. Epilepsia. 2018; 59:562–572. 10. Annegers JF, et al. Epilepsia 2000;41:549‐553. 11. Elliott RE, et al. Epilepsy Behav 2011;20(1):57‐63. 12. Kawai K, et al. Epileptic Disord 2017;19(3):1‐12. 13. Labar DR. Seizure 2004;13:392‐8. 14. Vonck K, et al. J Clin Neurophysiol 2004;21:283‐9 15. De Herdt V, et al. Eur J Paediatr Neurol 2007;11:261‐9. 16. Orosz I, et al. Epilepsia. 2014; 55(10):1576‐1584. 17. Englot DJ, et al. Epilepsy & Behavior. 2017; 66:4–9. 18. Helmers SL, et al. Epilepsy Behav. 2011 Oct;22(2):370‐5. 19. Bernstein A, et al. Epilepsy Behav 2007;10:134‐137. 20. Ben‐Menachem E J. Clin Neurophysiol 2001 Sep;18(5):415‐418. 21. Morris GL 3rd, et al. Neurology 1999 Nov 10;53(8):1731‐1735.

VNS Therapy is proven safe and effective for treating uncontrolled seizures in children and adults

VNS Therapy is the #1 prescribed device to treat epilepsy

>100,000 patients treated

VNS Therapy is the only device for drug-resistant epilepsy that is FDA-approved for 1.5T and 3T MRI

Introducing SenTiva and the Next-Generation Programming System

VNS Therapy controls seizures in 3 ways1

How VNS Therapy with responsive stimulation works

Detection and responsive stimulation during a seizure*5,6

Clinical Benefits

The benefits of VNS Therapy are seen early—often within 3 months7—and continue to improve out to 10 years8

Proven safe and effective

Most common adverse events with VNS Therapy diminish over time20,21

Publications

Patient Stories

Find out more here

VNS Therapy controls seizures in 3 ways¹

Detection and responsive stimulation during a seizure^*5,6

The benefits of VNS Therapy are seen early—often within 3 months⁷—and continue to improve out to 10 years⁸

Most common adverse events with VNS Therapy diminish over time^20,21